Epicardial adipose tissue density, myocardial fibrosis, and heart failure with preserved ejection fraction in postmenopausal women: a mediation analysis
Jia-Shen Jiang, Lei Li, Xiao-Yu Wang, Xi-Wu Ruan, Kou-Long Zheng, Dan Gao, Sheng Huang, Tian-Le Wang, Rong-Xing Qi · 2026
Read Epicardial adipose tissue density, myocardial fibrosis, and heart failure with preserved ejection fraction in postmenopausal women: a mediation analysis by Jia-Shen Jiang, Lei Li, Xiao-Yu Wang, Xi-Wu Ruan, Kou-Long Zheng, Dan Gao, Sheng Huang, Tian-Le Wang, Rong-Xing Qi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13350533.txt.
Description
Jia-Shen Jiang and eight co-authors probe in 2026 how fat around the heart relates to heart failure with preserved pumping in postmenopausal women. This failure type strikes women after menopause most, and its drivers stay murky. Epicardial fat hugs the heart muscle and can inflame it from outside.
Seventy patients and seventy matched controls underwent heart CT scans. The patient group carried more epicardial fat, denser fat, and more scarring in the heart wall. Denser fat stayed tied to the disease after risk factors were counted, and scarring carried part of fat's effect in mediation analysis. The fat-scar pathway suggests new targets for a condition that still lacks strong drug options.
Catalog record
| CREATOR | Jia-Shen Jiang, Lei Li, Xiao-Yu Wang, Xi-Wu Ruan, Kou-Long Zheng, Dan Gao, Sheng Huang, Tian-Le Wang, Rong-Xing Qi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |