Editorial: HDL and cardiovascular disease: mechanisms, clinical relevance, and therapeutic impacts

Jiayou Wang, Yanqiao Zhang · 2026

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Description

Jiayou Wang and Yanqiao Zhang edited a 2026 collection on HDL, the so-called good cholesterol, and cardiovascular disease. High HDL levels track with lower heart risk, yet trials that simply raised HDL with drugs failed to cut events, and genetic studies find no causal protection from the level itself.

Laboratory work still shows HDL particles directly protecting vessels and aiding metabolism in liver, immune, vessel wall, and pancreas cells. The collection shifts focus from how much HDL circulates to how well it works, gathering mechanisms, clinical relevance, and treatment ideas. Function-based measures may explain the trial disappointments and point to better targets.

Catalog record

CREATORJiayou Wang, Yanqiao Zhang
YEAR2026
COLLECTIONPAPERS
FORMATTXT
FILE SIZE4167
LICENSEhttps://creativecommons.org/licenses/by/4.0
RIGHTSCC BY
SOURCEEurope PMC

Source: https://europepmc.org/article/MED/PMC13350449

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