Persistent neurological and behavioral alterations after SARS-CoV-2 infection in an optimized K18-hACE2 mouse model
Carla Ruiz-Casas, Ferran Tarrés-Freixas, Núria Roca, Mònica Pérez, Estefania Contreras, Laura Martín, Olga Bernaus, Alex Olvera, Marta Ruiz-Riol, Christian Brander, Carla Usai, Júlia Vergara-Alert, Joaquim Segalés · 2026
Read Persistent neurological and behavioral alterations after SARS-CoV-2 infection in an optimized K18-hACE2 mouse model by Carla Ruiz-Casas, Ferran Tarrés-Freixas, Núria Roca, Mònica Pérez, Estefania Contreras, Laura Martín, Olga Bernaus, Alex Olvera, Marta Ruiz-Riol, Christian Brander, Carla Usai, Júlia Vergara-Alert, Joaquim Segalés (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13350038.txt.
Description
Carla Ruiz-Casas and colleagues tracked lasting brain effects of COVID infection in a specially bred mouse in a 2026 longitudinal study lasting 60 days. Long COVID affects over 30 percent of infected adults by some estimates, and its nerve and behaviour symptoms are among the most disabling.
Infected mice kept measurable thinking and behaviour problems even though no active virus was found in the brain. Immune disturbance persisted in lung and nerve tissue, lung damage lingered, and the vagus nerve shrank in cross-section. A faithful animal model that keeps symptoms after the virus clears gives researchers a way to test what drives long COVID and what might treat it.
Catalog record
| CREATOR | Carla Ruiz-Casas, Ferran Tarrés-Freixas, Núria Roca, Mònica Pérez, Estefania Contreras, Laura Martín, Olga Bernaus, Alex Olvera, Marta Ruiz-Riol, Christian Brander, Carla Usai, Júlia Vergara-Alert, Joaquim Segalés |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63418 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |