Integrative analysis of cuproptosis in kidney ischemia-reperfusion injury: biomarker discovery and diagnostic model construction
Chunyan Liang, Lixin Fu, Manling Xie, Changquan Zhang, Rong Ma, Chao Hu, Haibin Li, Ning Wen, Jiqiu Wen, Jianhui Dong, Xuyong Sun · 2026
Read Integrative analysis of cuproptosis in kidney ischemia-reperfusion injury: biomarker discovery and diagnostic model construction by Chunyan Liang, Lixin Fu, Manling Xie, Changquan Zhang, Rong Ma, Chao Hu, Haibin Li, Ning Wen, Jiqiu Wen, Jianhui Dong, Xuyong Sun (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13349827.txt.
Description
Chunyan Liang and colleagues searched for gene markers of kidney ischemia-reperfusion injury linked to cuproptosis, a copper-driven form of cell death, in a 2026 analysis. They mined public gene datasets, using one cohort for discovery, another for validation, and a third for single-cell work.
From the cuproptosis-related genes that changed in injured kidneys, they built a machine learning diagnostic model and checked it with a nomogram. Pathway and immune analyses showed which signals and immune cells tracked with the marker genes, and patient samples fell into distinct molecular subtypes. Gene changes were then confirmed in a mouse model of the injury. Such markers could speed diagnosis of a common cause of acute kidney injury.
Catalog record
| CREATOR | Chunyan Liang, Lixin Fu, Manling Xie, Changquan Zhang, Rong Ma, Chao Hu, Haibin Li, Ning Wen, Jiqiu Wen, Jianhui Dong, Xuyong Sun |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62630 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |