Hypertension worsens bone loss and weakens bone in aged ovariectomized mice
Elizabeth M Hennen, Sasidhar Uppuganti, Santosh Thapa, Néstor de la Visitación, Priya Mathiy, Gabriel Ramirez, Elizabeth Rendina-Ruedy, David G Harrison, Jeffry S Nyman · 2026
Read Hypertension worsens bone loss and weakens bone in aged ovariectomized mice by Elizabeth M Hennen, Sasidhar Uppuganti, Santosh Thapa, Néstor de la Visitación, Priya Mathiy, Gabriel Ramirez, Elizabeth Rendina-Ruedy, David G Harrison, Jeffry S Nyman (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13349054.txt.
Description
Elizabeth M Hennen and colleagues test whether high blood pressure deepens bone loss after estrogen loss, in a mouse study published in 2026. Twelve-month-old females had ovaries removed or left intact, then six weeks of angiotensin infusion to raise pressure. Bone density, femur shape, and breaking strength were tracked before and after each stage.
Ovary removal alone cut whole-body density, yet pressure plus removal together thinned thigh cortical bone and weakened both thigh and spine beyond either hit alone in the reported tests. Spongy bone losses added up in the combined group, which hit the lowest values, backing extra fracture care for postmenopausal women with hypertension.
Catalog record
| CREATOR | Elizabeth M Hennen, Sasidhar Uppuganti, Santosh Thapa, Néstor de la Visitación, Priya Mathiy, Gabriel Ramirez, Elizabeth Rendina-Ruedy, David G Harrison, Jeffry S Nyman |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54490 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |