The Ontogeny of Rhythms in Circadian Clock Gene Expression in Mouse Brain and Neuroimmune Tissues
Kiersten S Bell, Ruizhuo Chen, Aidan S Weitzner, Laura K Fonken · 2026
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Description
Kiersten S Bell and colleagues trace when daily clock rhythms appear in the developing mouse brain, in a study from 2026. Male and female pups on a set light cycle were sampled from day 1 to day 24 for three clock genes in the master clock, memory. Control brain areas, plus immune tissues and blood hormone pulses.
Rhythms showed in hormone levels and every brain area, growing stronger and settling toward adult timing by day 24 in the reported pattern. Two immune border tissues showed clock swings by mid development. While isolated microglia showed no clock swing yet still ate particles on a daily rhythm, so function can tick before genes visibly do.
Catalog record
| CREATOR | Kiersten S Bell, Ruizhuo Chen, Aidan S Weitzner, Laura K Fonken |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64046 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |