Oxidative stress biomarkers across mood episodes in bipolar disorder: potential roles of TrxR1 and PRDX1
Onur Gökçen, Kader Semra Karataş, Merve Akkuş, Feyza Dönmez, Ayşe Koçak Sezgin, Meliha Koldemir Gündüz, Güllü Kaymak · 2026
Read Oxidative stress biomarkers across mood episodes in bipolar disorder: potential roles of TrxR1 and PRDX1 by Onur Gökçen, Kader Semra Karataş, Merve Akkuş, Feyza Dönmez, Ayşe Koçak Sezgin, Meliha Koldemir Gündüz, Güllü Kaymak (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13348687.txt.
Description
Onur Gökçen and co-authors compare oxidative stress markers in bipolar patients across mood states and against healthy peers, in this 2026 study. One hundred one patients, split among calm, depressed, and manic phases, plus twenty-nine controls, gave blood for a panel of antioxidant measures. Two genes' variants were typed as well. Patients overall ran higher on total antioxidant status and on two protective enzymes.
Their glutathione, another defender, ran lower. The two enzymes, TrxR1 and PRDX1, separated patients from controls sharply, a first report for both in this illness. Mood phase itself barely moved any marker. One gene variant tied to higher enzyme levels. The authors nominate the pair as candidate blood markers for bipolar disorder itself rather than its episodes.
Catalog record
| CREATOR | Onur Gökçen, Kader Semra Karataş, Merve Akkuş, Feyza Dönmez, Ayşe Koçak Sezgin, Meliha Koldemir Gündüz, Güllü Kaymak |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |