Synthesis and Biological Evaluation of 4‑Bromo-N,N-dimethyltryptamine (4-Br-DMT): A Synthetic Building Block for Future Analog Development
Elena Bray, Grant C. Glatfelter, Alexander D. Maitland, Nicholas R. Gonzalez, Donna Walther, Jeanine Yacoub, Michael H. Baumann, Jacqueline L. von Salm · 2026
Read Synthesis and Biological Evaluation of 4‑Bromo-N,N-dimethyltryptamine (4-Br-DMT): A Synthetic Building Block for Future Analog Development by Elena Bray, Grant C. Glatfelter, Alexander D. Maitland, Nicholas R. Gonzalez, Donna Walther, Jeanine Yacoub, Michael H. Baumann, Jacqueline L. von Salm (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13347390.txt.
Description
Elena Bray and colleagues synthesise a brominated tryptamine and profile its biology as a base for new analogues, in a study from 2026. The compound, 4-Br-DMT, was built as a late-stage hub so palladium coupling could attach varied carbon groups at the 4-position, speeding a library of ring-swapped tryptamines for receptor studies.
Direct tests compared the new compound with psilocin and plain DMT on serotonin targets and in mice, and the profile stayed serotonergic in the reported assays. Unlike its comparators, it showed no psychedelic-like effects in mice, yet its safety margin looked weaker than both reference drugs. The route, more than this single compound, is the main offer for analogue hunters.
Catalog record
| CREATOR | Elena Bray, Grant C. Glatfelter, Alexander D. Maitland, Nicholas R. Gonzalez, Donna Walther, Jeanine Yacoub, Michael H. Baumann, Jacqueline L. von Salm |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37701 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |