SHP1 expression in tumor-associated dendritic cells drives immunoevasion via impairing CD8+ memory T cell responses
Gao Yu, Yusheng Liang, Weize Yu, Gaojian Zhuang, Bing Li, Jiayi Huang, Jinghao Zheng, Xuanqi Yang, Leyun Wen, Xiaoming Tan, Yuan Zhang · 2026
Read SHP1 expression in tumor-associated dendritic cells drives immunoevasion via impairing CD8+ memory T cell responses by Gao Yu, Yusheng Liang, Weize Yu, Gaojian Zhuang, Bing Li, Jiayi Huang, Jinghao Zheng, Xuanqi Yang, Leyun Wen, Xiaoming Tan, Yuan Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13347042.txt.
Description
Gao Yu and colleagues published a 2026 cancer immunology study on dendritic cells. These cells teach killer T cells to attack tumors. A brake protein inside them weakens that teaching. Tumors exploit the brake to escape immunity. The team removed the brake in mice.
Without it, dendritic cells activated more strongly. Tumors grew less in two mouse models. Memory T cells formed in greater numbers. Gene analysis traced the effect to an interferon pathway. Blocking the brake also improved existing immunotherapy in earlier work. The findings nominate this protein as a drug target. Stronger teaching cells could make treatments last longer.
Catalog record
| CREATOR | Gao Yu, Yusheng Liang, Weize Yu, Gaojian Zhuang, Bing Li, Jiayi Huang, Jinghao Zheng, Xuanqi Yang, Leyun Wen, Xiaoming Tan, Yuan Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |