A retrospective pharmacovigilance analysis based on the FAERS database reveals sex-associated differences in toxicities of CAR T-cell therapy
Yuan Liu, Jingwen Yang, Madiha Iqbal, Mehmet Uyanik, Mei Luo, Liqi Yang, Yanyan Lou, Lixia Diao, Olalekan O. Oluwole, Javid J. Moslehi, Douglas B. Johnson, Leng Han · 2026
Read A retrospective pharmacovigilance analysis based on the FAERS database reveals sex-associated differences in toxicities of CAR T-cell therapy by Yuan Liu, Jingwen Yang, Madiha Iqbal, Mehmet Uyanik, Mei Luo, Liqi Yang, Yanyan Lou, Lixia Diao, Olalekan O. Oluwole, Javid J. Moslehi, Douglas B. Johnson, Leng Han (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13347020.txt.
Description
Yuan Liu and co-authors mine a United States safety database for sex-linked gaps in harms from CAR T-cell therapy in a 2026 study. This cancer treatment retools immune cells to attack blood cancers, but it can cause severe side effects. Whether those harms fall differently on women and men had been little studied.
The team pulled all reports tied to the therapy from the federal database, some seventy-seven hundred cases in all. Women showed higher reporting odds for a strong immune overreaction and for later leukemias, with higher odds across many organ systems too. The pattern did not match sex gaps seen in other cancer treatments. The authors say sex should be weighed when teams plan how to watch for and handle these harms.
Catalog record
| CREATOR | Yuan Liu, Jingwen Yang, Madiha Iqbal, Mehmet Uyanik, Mei Luo, Liqi Yang, Yanyan Lou, Lixia Diao, Olalekan O. Oluwole, Javid J. Moslehi, Douglas B. Johnson, Leng Han |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |