Neural Responses to Affective Sentences Reveal Signatures of Depression
Aditya Kommineni, Woojae Jeong, Kleanthis Avramidis, Colin McDaniel, Myzelle Hughes, Thomas McGee, Elsi Kaiser, Kristina Lerman, Idan A. Blank, Dani Byrd, Assal Habibi, B. Rael Cahn, Sudarsana Kadiri, Takfarinas Medani, Richard M. Leahy, Shrikanth Narayanan · 2026
Read Neural Responses to Affective Sentences Reveal Signatures of Depression by Aditya Kommineni, Woojae Jeong, Kleanthis Avramidis, Colin McDaniel, Myzelle Hughes, Thomas McGee, Elsi Kaiser, Kristina Lerman, Idan A. Blank, Dani Byrd, Assal Habibi, B. Rael Cahn, Sudarsana Kadiri, Takfarinas Medani, Richard M. Leahy, Shrikanth Narayanan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13346668.txt.
Description
Aditya Kommineni and a large team record neural responses to affective sentences to reveal signatures of depression. Major depressive disorder is highly prevalent, and how it alters the processing of emotional and self-referential information is still being mapped. Their 2026 study sets scalp electroencephalography sensors on healthy adults and on adults with depression. Sentences referring to the self and carrying feeling flashed on a screen while the sensors caught the brain's fast responses.
The two groups' neural activity differed significantly during sentence viewing. The difference hints at disrupted binding of feeling and self information in depression. A deep learning model trained on the responses separated the groups with fair skill, reaching an accuracy area of 0.72. It did less well, at 0.65, at splitting depressed subgroups by suicidal thinking. Front sensors tied to meaning and feeling did most of the work. The team sees a path toward screening tools.
Catalog record
| CREATOR | Aditya Kommineni, Woojae Jeong, Kleanthis Avramidis, Colin McDaniel, Myzelle Hughes, Thomas McGee, Elsi Kaiser, Kristina Lerman, Idan A. Blank, Dani Byrd, Assal Habibi, B. Rael Cahn, Sudarsana Kadiri, Takfarinas Medani, Richard M. Leahy, Shrikanth Narayanan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |