Targeting lysine-specific demethylase 1 inhibits melanoma metastasis via the NF2-Hippo-YAP pathway
Han Yang, Yanli Ding, Yuxing Wang, Shuzhen Wei, Weizhen Cao, Yichao Xu, Pengxing He, Linlin Chang · 2026
Read Targeting lysine-specific demethylase 1 inhibits melanoma metastasis via the NF2-Hippo-YAP pathway by Han Yang, Yanli Ding, Yuxing Wang, Shuzhen Wei, Weizhen Cao, Yichao Xu, Pengxing He, Linlin Chang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13346636.txt.
Description
Han Yang and co-authors show that blocking a gene-trimming enzyme can slow melanoma spread in work dated two thousand twenty-six. Melanoma starts in skin pigment cells and spreads with ease, and few treatments stop that spread. The enzyme, LSD1, edits marks on the proteins that pack DNA.
Levels of the enzyme were higher in spread tumors than in first tumors, and high levels tracked with poor outlook. Blocking the enzyme, by drug or by gene tools, curbed spread in cell and animal tests. The block switched on a brake path in the cell, which tagged a growth driver for disposal. Gene tests showed the block also raised marks that switch on the brake genes themselves.
Catalog record
| CREATOR | Han Yang, Yanli Ding, Yuxing Wang, Shuzhen Wei, Weizhen Cao, Yichao Xu, Pengxing He, Linlin Chang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |