Exploitation of cholesterol-dependent cytolysins for targeted biosensing and therapeutic systems
Henry O. Abanum, Ethan Watt, Emmanuel A. Ho · 2026
Read Exploitation of cholesterol-dependent cytolysins for targeted biosensing and therapeutic systems by Henry O. Abanum, Ethan Watt, Emmanuel A. Ho (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13346216.txt.
Description
Henry Abanum, Ethan Watt, and Emmanuel Ho review bacterial toxins that punch holes in cell membranes, in a 2026 paper. These toxins, called cholesterol-dependent cytolysins, come from disease-causing bacteria and help them infect hosts. They bind cholesterol-rich membranes and reshape to form pores.
That same targeting can be turned to good use. The review covers toxin-based sensors for finding pathogens, carriers that deliver drugs to set places, and vaccine ideas. It also covers design factors for materials that respond to these toxins. Promising lab and animal results exist, but moving to the clinic faces hurdles the authors discuss in detail.
Catalog record
| CREATOR | Henry O. Abanum, Ethan Watt, Emmanuel A. Ho |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |