IFN-I exacerbates the inflammatory response of epithelial cells to Chlamydia trachomatis infection by enhancing TLR3 expression
Chongfa Tang, Xiaonan Cai, Béatrice Niragire, Félix V. Louchez, Yaël Victoria Levy-Zauberman, Agathe Subtil, Yongzheng Wu · 2026
Read IFN-I exacerbates the inflammatory response of epithelial cells to Chlamydia trachomatis infection by enhancing TLR3 expression by Chongfa Tang, Xiaonan Cai, Béatrice Niragire, Félix V. Louchez, Yaël Victoria Levy-Zauberman, Agathe Subtil, Yongzheng Wu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13344013.txt.
Description
Chongfa Tang and co-authors show that a frontline antiviral signal can backfire during chlamydia infection in 2026. Type I interferon alone did nothing to genital epithelial cells, yet paired with Chlamydia trachomatis it fired inflammation far beyond what the bacterium triggered by itself, a synergy with tissue-damaging potential.
The team traced the effect to interferon raising levels of Toll-like receptor 3, a sensor that detects leftover viral-style RNA inside infected cells. Silencing or deleting that receptor killed the synergy, while blocking AKT, mTOR, or ERK signaling also dampened it. Downstream cascades through MAPK and AP-1 completed the chain. Calming these pathways could limit the overinflammation some patients suffer.
Catalog record
| CREATOR | Chongfa Tang, Xiaonan Cai, Béatrice Niragire, Félix V. Louchez, Yaël Victoria Levy-Zauberman, Agathe Subtil, Yongzheng Wu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44206 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |