Prevotella bivia promotes cervical cancer progression and modulates macrophage polarization, while Lactobacillus iners suppresses these processes: evidence from multiomics analysis
Ting Zhang, Qiuhong Qian, Qianwei Zhen, Jiaxin Zhang, Yu Sun, Junhua Zhang, Lingyu Guo, Xiaoli Liu, Deyuan Zou, Baokun Zhou, Chang Liu, Shuqi Chi, Gaishuang Shang, Baoxia Cui, Youzhong Zhang, Yunlong Cui, Youming Zhang, Sai Han · 2026
Read Prevotella bivia promotes cervical cancer progression and modulates macrophage polarization, while Lactobacillus iners suppresses these processes: evidence from multiomics analysis by Ting Zhang, Qiuhong Qian, Qianwei Zhen, Jiaxin Zhang, Yu Sun, Junhua Zhang, Lingyu Guo, Xiaoli Liu, Deyuan Zou, Baokun Zhou, Chang Liu, Shuqi Chi, Gaishuang Shang, Baoxia Cui, Youzhong Zhang, Yunlong Cui, Youming Zhang, Sai Han (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13344011.txt.
Description
Ting Zhang and a large team profile microbes living inside cervical tumors in 2026. Tumor tissue carried richer bacterial growth than healthy cervix, and two species stood out for lab follow-up: Prevotella bivia and Lactobacillus iners, which pulled tumor behavior in opposite directions.
Higher Prevotella levels tracked with deeper invasion, larger tumors, later stage, and poorer survival. In dishes and mice, P. bivia sped cancer cell movement and invasion and pushed macrophages toward a tumor-helping M2 state through STAT3 and NF-kB signaling, while L. iners slowed growth and raised cell death. Both microbes fed into the PI3K/AKT/mTOR pathway, and glycine emerged as a possible key metabolite linking them.
Catalog record
| CREATOR | Ting Zhang, Qiuhong Qian, Qianwei Zhen, Jiaxin Zhang, Yu Sun, Junhua Zhang, Lingyu Guo, Xiaoli Liu, Deyuan Zou, Baokun Zhou, Chang Liu, Shuqi Chi, Gaishuang Shang, Baoxia Cui, Youzhong Zhang, Yunlong Cui, Youming Zhang, Sai Han |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48654 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |