Determination of the peroxisomal proteome of pathogenic stage Histoplasma capsulatum
Peter J. Brechting, Chad A. Rappleye · 2026
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Description
Peter J. Brechting and Chad A. Rappleye mapped the peroxisome protein set in 2026 in disease phase Histoplasma yeasts during infection. Inside host phagocytes, Histoplasma beats defences and grows within phagosomes, a process needing peroxisome function for many poorly mapped roles. Early disease depends on proper trafficking of peroxisome matrix proteins carrying a type 1 targeting signal.
Proximity labelling with a peroxisome targeted TurboID biotin ligase named peroxisome proteins, with comparative proteomics against cytosol controls. The protein map shows which peroxisome proteins back growth inside cells. The findings point to fungal peroxisome biology as a possible weak spot in histoplasmosis.
Catalog record
| CREATOR | Peter J. Brechting, Chad A. Rappleye |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |