Curcumin-loaded dynamic crosslinked injectable hydrogel for annulus fibrosus repair and disc degeneration prevention
Qi Zhang, Mingyang Kang, Rongpeng Dong, Xiaokui Tang, Yang Qu · 2026
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Description
Qi Zhang and four co-authors built an injectable gel to repair the spine's shock absorbers in a 2026 paper. After surgery for a slipped disc, tears in the outer ring, the annulus fibrosus, often lead to repeat herniation and faster wear. The ring heals poorly on its own, so a filler that supports, sticks, and calms inflammation could help.
Their gel carries curcumin, a plant compound, inside tiny lipid bubbles within a self-linking network. It sets in about a minute and matches the native ring's stiffness. In rabbits with ring defects, the treatment held disc height and lowered inflammatory signals while supporting the disc's matrix. The authors present the gel as a combined repair and prevention tool.
Catalog record
| CREATOR | Qi Zhang, Mingyang Kang, Rongpeng Dong, Xiaokui Tang, Yang Qu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |