Multi-cohort proteogenomic analyses reveal genetic effects across the proteome and diseasome
Mine Koprulu, Karl Smith-Byrne, Brian Richard Ferolito, Erin Macdonald-Dunlop, Jian’an Luan, Åsa K. Hedman, Chibuzor Franklin Ogamba, Jurgis Kuliesius, Linda Repetto, Anna Ramisch, Fahim Abbasi, Johan Ärnlöv, Themistocles L. Assimes, BeLOVE Study Group, Hanna M. Björck, Sophia Björkander, Morten Böt · 2026
Read Multi-cohort proteogenomic analyses reveal genetic effects across the proteome and diseasome by Mine Koprulu, Karl Smith-Byrne, Brian Richard Ferolito, Erin Macdonald-Dunlop, Jian’an Luan, Åsa K. Hedman, Chibuzor Franklin Ogamba, Jurgis Kuliesius, Linda Repetto, Anna Ramisch, Fahim Abbasi, Johan Ärnlöv, Themistocles L. Assimes, BeLOVE Study Group, Hanna M. Björck, Sophia Björkander, Morten Böt (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13343581.txt.
Description
Mine Koprulu and a large multi-cohort team reported the biggest proteogenomic study to date in a 2026 paper. Knowing how genes regulate blood protein levels can reveal disease pathways. The team combined data from tens of thousands of participants across thirty-eight studies.
They found over twenty-four thousand genetic loci tied to more than eleven hundred proteins, acting near or far from the gene involved. Machine learning assigned likely effector genes, and one sugar-tagging pathway stood out as a strong regulator. Comparing instruments for protein production versus modulation gave distinct disease insights. Several proteins emerged as drug target candidates, and some existing drugs, such as a class used for joint disease, looked repositionable.
Catalog record
| CREATOR | Mine Koprulu, Karl Smith-Byrne, Brian Richard Ferolito, Erin Macdonald-Dunlop, Jian’an Luan, Åsa K. Hedman, Chibuzor Franklin Ogamba, Jurgis Kuliesius, Linda Repetto, Anna Ramisch, Fahim Abbasi, Johan Ärnlöv, Themistocles L. Assimes, BeLOVE Study Group, Hanna M. Björck, Sophia Björkander, Morten Böt |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |