Mitochondrial transplantation reverses the senescence phenotype of SH-SY5Y cells
Liqun Xu, Yilang Wu, Wanfei Wu, Xiao Li, Ronghao Deng, Haibao Zhu, Aihua Mao, Pingnan Sun, Xin Zhang, Wencan Xu, Chi-ju Wei · 2026
Read Mitochondrial transplantation reverses the senescence phenotype of SH-SY5Y cells by Liqun Xu, Yilang Wu, Wanfei Wu, Xiao Li, Ronghao Deng, Haibao Zhu, Aihua Mao, Pingnan Sun, Xin Zhang, Wencan Xu, Chi-ju Wei (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13343158.txt.
Description
Liqun Xu and co-authors test mitochondrial transplantation in aged lab cells in 2026, using the human neuroblastoma line SH-SY5Y as a stand-in for sick neurons. Faulty mitochondria sit at the heart of Parkinson disease, so the team asked whether delivering fresh mitochondria could undo the worn-out state of senescent cells.
Engineered membrane vesicles fused with the cells and dropped off working mitochondria, confirmed by DNA fingerprint tracing. Energy output, glucose use, and breathing capacity returned near normal, harmful secretion patterns eased, and cell death resistance rose. Alpha-synuclein fell while dopamine making recovered. The authors present organelle transfer as a possible route against neurodegenerative decline.
Catalog record
| CREATOR | Liqun Xu, Yilang Wu, Wanfei Wu, Xiao Li, Ronghao Deng, Haibao Zhu, Aihua Mao, Pingnan Sun, Xin Zhang, Wencan Xu, Chi-ju Wei |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51104 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |