Rapid Human Skin Barrier Disruption by Sodium Dodecyl Sulfate and Associated Molecular Mechanisms
Manru Li, Huseyn Babayev, Paolo D'Avino, Can Zeyneloğlu, Ceren Bicer, Duygu Yazici, Yagiz Pat, Per Svedenhag, Nicolas Gaudenzio, Cezmi A Akdis, Yasutaka Mitamura · 2026
Read Rapid Human Skin Barrier Disruption by Sodium Dodecyl Sulfate and Associated Molecular Mechanisms by Manru Li, Huseyn Babayev, Paolo D'Avino, Can Zeyneloğlu, Ceren Bicer, Duygu Yazici, Yagiz Pat, Per Svedenhag, Nicolas Gaudenzio, Cezmi A Akdis, Yasutaka Mitamura (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13342777.txt.
Description
Manru Li and co-authors published a study in 2026 on how sodium dodecyl sulfate, a common surfactant in household cleaning products, rapidly disrupts the human skin barrier. Breakdown of the skin barrier is a hallmark of allergic skin diseases, and the surfactant is known to harm it.
The researchers exposed human skin samples in the laboratory and monitored barrier integrity in real time with an electrical measurement technique. Even a one-minute exposure caused an immediate decline, indicating rapid barrier compromise. Five-minute exposures produced a dose-dependent decline, suppressing barrier and immune signaling molecules. A six-hour exposure sustained the barrier loss. Deep analyses of gene activity and proteins showed stress and repair pathways switched on, while barrier and immune markers were damped down. Two stood out as signs of skin damage. Two protective compounds reduced the harm in cultured skin cells and in lab skin samples.
Catalog record
| CREATOR | Manru Li, Huseyn Babayev, Paolo D'Avino, Can Zeyneloğlu, Ceren Bicer, Duygu Yazici, Yagiz Pat, Per Svedenhag, Nicolas Gaudenzio, Cezmi A Akdis, Yasutaka Mitamura |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |