Mitochondrial OPerA: tuning retrograde signaling and empowering intratumoral cDC1s
Bhavana Kushwaha, Ruoning Wang · 2026
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Description
Bhavana Kushwaha and Ruoning Wang comment in 2026 on work by You and colleagues about a mitochondrial protein called OPA1 in tumor dendritic cells. Their commentary centers on conventional type 1 dendritic cells, key immune cells that often lose strength inside solid tumors and fail to rally an attack.
You and colleagues found that falling OPA1 levels track with weaker mitochondria and fading cell function, acting through a signaling path involving NRF1. Giving mice dendritic cells with polarized, fitter mitochondria sparked strong immune responses against tumors. Kushwaha and Wang frame the result as metabolic immunotherapy: fixing immune cell energy systems might rescue treatments that most patients currently resist.
Catalog record
| CREATOR | Bhavana Kushwaha, Ruoning Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 10125 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |