Folate-targeted PLGA nanoparticles enhance paclitaxel-induced cytotoxicity and apoptosis in B16 melanoma cells
Zena Hasan Sahib, Entisar Al-Muhktar, Fizel Alhimyari, Entidhar Jasim Khamees · 2026
Read Folate-targeted PLGA nanoparticles enhance paclitaxel-induced cytotoxicity and apoptosis in B16 melanoma cells by Zena Hasan Sahib, Entisar Al-Muhktar, Fizel Alhimyari, Entidhar Jasim Khamees (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13342639.txt.
Description
Zena Hasan Sahib and co-authors dress a cancer drug in tiny targeted capsules to fight melanoma in the lab. The drug, paclitaxel, works but dissolves poorly and spreads through the body, causing side effects. The team loaded it into biodegradable particles and tagged them with folate, a vitamin that many tumor cells grab.
In melanoma cell tests, the tagged particles cut living cells to about 26 in a hundred, far below free drug at 59 and untagged particles at 43. Cell-death assays matched that lead. The folate tag seems to steer more drug into the cells. Animal and human tests would come next.
Catalog record
| CREATOR | Zena Hasan Sahib, Entisar Al-Muhktar, Fizel Alhimyari, Entidhar Jasim Khamees |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |