Oleuropein attenuates steroid-induced osteonecrosis of the femoral head by inhibiting osteoblast apoptosis via activation of the PI3K-AKT-Bcl2 pathway
Jianlong Lin, Rui Zhang, Xingyu Lin, Xiangjun Luo, Haokun Lin, Jie Xu, Shishui Lin · 2026
Read Oleuropein attenuates steroid-induced osteonecrosis of the femoral head by inhibiting osteoblast apoptosis via activation of the PI3K-AKT-Bcl2 pathway by Jianlong Lin, Rui Zhang, Xingyu Lin, Xiangjun Luo, Haokun Lin, Jie Xu, Shishui Lin (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13342593.txt.
Description
Jianlong Lin and co-authors test oleuropein, a plant compound, against steroid-driven death of the hip bone head. Long steroid use can starve the femoral head and kill its bone-forming cells, a severe disorder with few good fixes. Oleuropein fights inflammation and oxidation and has guarded bone cells in other settings.
Their 2026 study works in cell dishes and in rats. Bone-forming cells dosed with a steroid were shielded by the compound in viability tests. In rats, the disease was induced and then treated, with bone structure read by fine scans and tissue stains. Network and protein analyses point to the PI3K-AKT-Bcl2 path, which the compound switches on to hold back cell death.
Catalog record
| CREATOR | Jianlong Lin, Rui Zhang, Xingyu Lin, Xiangjun Luo, Haokun Lin, Jie Xu, Shishui Lin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |