Low-intensity pulsed ultrasound promotes peripheral nerve regeneration by alleviating Schwann cells pyroptosis
Junfeng Chen, Lu Yu, Yansong Lu, Yufei Zhang, Cheng-kung Cheng, Yifei Yao · 2026
Read Low-intensity pulsed ultrasound promotes peripheral nerve regeneration by alleviating Schwann cells pyroptosis by Junfeng Chen, Lu Yu, Yansong Lu, Yufei Zhang, Cheng-kung Cheng, Yifei Yao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13342520.txt.
Description
After a peripheral nerve is crushed, recovery depends on Schwann cells, the support cells that clear debris and guide regrowth. Chen and co-authors test whether gentle pulsed ultrasound can help those cells survive and work better.
In rats with a crushed sciatic nerve, the ultrasound treatment improved movement, sped regrowth of the nerve fibers and their insulation, and reduced wasting of the calf muscle. The team traced the effect to the cells' power plants: ultrasound eased mitochondrial failure in Schwann cells, which shut down a fiery form of cell death called pyroptosis. With less of that death, fewer inflammatory signals spilled out, and the cells multiplied, migrated, and cleared debris more effectively. The result was a friendlier setting for repair.
Catalog record
| CREATOR | Junfeng Chen, Lu Yu, Yansong Lu, Yufei Zhang, Cheng-kung Cheng, Yifei Yao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |