A membrane-modulated chemoenzymatic dynamic kinetic resolution for the synthesis of chiral phthalidyl esters
Jun Wu, Donghua He, Yongjin Zhang, Zhendong Feng, Hongxu Liu, Guohua Liu · 2026
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Description
Jun Wu and co-authors present a 2026 chemistry paper on keeping two quarreling catalysts apart so both can work. Dynamic kinetic resolution makes chiral molecules by racemizing one mirror form while an enzyme converts it, but the two catalysts often poison each other. Their fix is a membrane that separates the steps in space while letting the chemistry flow.
Run as a two-stage process, the system no longer demands the strict speed matching that hobbles classic setups. Efficiency climbed sharply over the conventional route. The products are chiral phthalide esters with crowded, fully substituted centers that older methods struggle to reach. Tuning also became simpler, since each stage can be adjusted on its own. The authors offer the membrane trick as a general platform for mixed catalysis.
Catalog record
| CREATOR | Jun Wu, Donghua He, Yongjin Zhang, Zhendong Feng, Hongxu Liu, Guohua Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |