Prospective natural history and clinical biomarkers of EYS-associated retinopathy in the KEYS study
Marika Taniguchi, Yuki Togashi, Satoshi Yokota, Masakazu Hiraoka, Shohei Kitahata, Natsuko Nakamura, Midori Yamamoto, Michiko Mandai, Kiyoko Gocho, Masanao Toshimori, Yasuhiko Hirami, Fumi Gomi, Yasuo Kurimoto, Akiko Maeda · 2026
Read Prospective natural history and clinical biomarkers of EYS-associated retinopathy in the KEYS study by Marika Taniguchi, Yuki Togashi, Satoshi Yokota, Masakazu Hiraoka, Shohei Kitahata, Natsuko Nakamura, Midori Yamamoto, Michiko Mandai, Kiyoko Gocho, Masanao Toshimori, Yasuhiko Hirami, Fumi Gomi, Yasuo Kurimoto, Akiko Maeda (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13342466.txt.
Description
Marika Taniguchi and co-authors wrote a study from 2026 tracking an inherited eye disease tied to one gene, named EYS. The gene is a leading cause of a recessive form of retinitis pigmentosa, above all in Asia. It is a prime target for gene therapies. Yet doctors lacked markers for how fast the disease moves. The KEYS study followed patients to test candidate markers.
Forty-nine patients at one eye hospital in Kobe were watched for two years. Vision field tests and layer scans of the retina were taken on a schedule. Over the two years, the field shrank in both center and surround, and the width of a key light-sensing layer narrowed. The links between field loss and layer width showed mainly in patients who began with better scores. The team names those gauges as useful markers, with strength that varies by stage.
Catalog record
| CREATOR | Marika Taniguchi, Yuki Togashi, Satoshi Yokota, Masakazu Hiraoka, Shohei Kitahata, Natsuko Nakamura, Midori Yamamoto, Michiko Mandai, Kiyoko Gocho, Masanao Toshimori, Yasuhiko Hirami, Fumi Gomi, Yasuo Kurimoto, Akiko Maeda |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |