Simulated microgravity-driven mechanical unloading rescues PIEZO1-overexpression-induced growth plate ossification and retards adolescent idiopathic scoliosis
Fei Chen, Shuqing Chen, Xingzhi Jing, Fushuai Peng, Yukun Du, Jianyi Li, Yuanyuan Fan, Zichen Cui, Guanghui Gu, Han Zhang, Jun Dong, Tao Li, Yongming Xi · 2026
Read Simulated microgravity-driven mechanical unloading rescues PIEZO1-overexpression-induced growth plate ossification and retards adolescent idiopathic scoliosis by Fei Chen, Shuqing Chen, Xingzhi Jing, Fushuai Peng, Yukun Du, Jianyi Li, Yuanyuan Fan, Zichen Cui, Guanghui Gu, Han Zhang, Jun Dong, Tao Li, Yongming Xi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13342308.txt.
Description
Fei Chen and eleven co-workers probed an odd cure for curved spines in teens: less load on the spine. The bent spine gets worse when too much force stirs a sensor protein called PIEZO1 in growth plate cells. Less load is most often linked to harm in muscle and bone in space flight. The 2026 study joined checks on patients, tests in mice, and lab work on cells to see if less load could help for once.
Pull with no weight load cut the spine curve in one bad case. In mice, pull each day slowed the bend, and hang by the tail undid harm from force. In cells, force raised PIEZO1 and pushed growth cells toward bone. Fake zero gravity undid that shift. A drug that turns PIEZO1 on proved its bad role. Less load may be a tool to treat this bent spine state.
Catalog record
| CREATOR | Fei Chen, Shuqing Chen, Xingzhi Jing, Fushuai Peng, Yukun Du, Jianyi Li, Yuanyuan Fan, Zichen Cui, Guanghui Gu, Han Zhang, Jun Dong, Tao Li, Yongming Xi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |