CircPTP4A2 (hsa_circ_0007364) promotes growth and invasion of non-small cell lung cancer by regulating miR-183-5p/EEF2 axis
Qiuping Shen, Hao Jin, Xiaofeng Zhu · 2026
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Description
Qiuping Shen and co-authors show a circular RNA drives growth and invasion in non-small cell lung cancer through a microRNA axis. The same RNA was earlier tied to cervical cancer. Its role in lung tumors had stayed unknown.
Levels ran high in tumor tissue and cell lines. High levels marked patients with poorer outlook. Silencing the RNA slowed cell growth and spread in dishes. It works by soaking up a small regulatory RNA. That frees a growth protein called EEF2 to rise. Patient samples confirmed the inverse pattern in real tumors. The axis names fresh targets for lung cancer drugs. It also offers a possible marker for prognosis.
Catalog record
| CREATOR | Qiuping Shen, Hao Jin, Xiaofeng Zhu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |