A DPP inhibitor suppresses periodontitis via antibacterial effect targeting Porphyromonas gingivalis
Yukari Aoki-Nonaka, Yukako Minato, Koushi Hidaka, Yuko Warita, Daiki Ando, Hnin Yu Lwin, Aoi Matsugishi-Nasu, Naoki Takahashi, Akihiro Nakamura, Wataru Ogasawara, Mizuki Sekiya, Yasumitsu Sakamoto, Koichi Tabeta · 2026
Read A DPP inhibitor suppresses periodontitis via antibacterial effect targeting Porphyromonas gingivalis by Yukari Aoki-Nonaka, Yukako Minato, Koushi Hidaka, Yuko Warita, Daiki Ando, Hnin Yu Lwin, Aoi Matsugishi-Nasu, Naoki Takahashi, Akihiro Nakamura, Wataru Ogasawara, Mizuki Sekiya, Yasumitsu Sakamoto, Koichi Tabeta (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13342067.txt.
Description
Yukari Aoki-Nonaka and co-authors design a drug that starves the main gum disease bacterium of a tool it needs, in a 2026 study. The germ Porphyromonas gingivalis uses an enzyme, PgDPP7, from a family mammals do not have, making it a clean target. Guided by crystal structures, the team built dipeptide blockers and found a lead compound, KGDI-109.
The compound halted the germ's growth at low concentration and spared other mouth bacteria. In mice with induced gum disease, oral dosing cut bone loss around the teeth and lowered the germ's numbers. It may also disturb gut microbes less than a standard antibiotic. The authors present it as a new, narrow-spectrum route against periodontitis.
Catalog record
| CREATOR | Yukari Aoki-Nonaka, Yukako Minato, Koushi Hidaka, Yuko Warita, Daiki Ando, Hnin Yu Lwin, Aoi Matsugishi-Nasu, Naoki Takahashi, Akihiro Nakamura, Wataru Ogasawara, Mizuki Sekiya, Yasumitsu Sakamoto, Koichi Tabeta |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |