Design of dual-effect molecules based on lysosome-targeting strategy: a mechanistic study on synergistic inhibition of ewing sarcoma and coronaviruses
Shimeng Zhou, Lu Xu, Wenlong Ge · 2026
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Description
One molecule aimed at both a bone cancer and coronaviruses is designed by Shimeng Zhou's team in a 2026 study. Their strategy targets lysosomes, the acidic compartments that tumors and viruses both exploit, using a side chain that concentrates the compound there.
The synthesized molecule neutralized lysosomal pH, stalled autophagy, raised stress signals, activated p53, and pushed cells into apoptosis. It blocked Ewing sarcoma cells at an IC50 of 25 μM, also hit prostate cancer bone metastasis cells, and suppressed two pig coronaviruses. Dual-action agents like this could sidestep both chemotherapy toxicity and viral drug resistance, the authors propose.
Catalog record
| CREATOR | Shimeng Zhou, Lu Xu, Wenlong Ge |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40738 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |