CCT2 regulates the proliferation, apoptosis, and cell cycle arrest of multiple myeloma cells through the P53 signalling pathway
Hongxiu Wang, Xiaomin Chen, Yang Liu, Siqi Wang, Qiuyu Xiang, Yu Zhao, Lixiu Luo, Yanling Wu, Chunlan Huang · 2026
Read CCT2 regulates the proliferation, apoptosis, and cell cycle arrest of multiple myeloma cells through the P53 signalling pathway by Hongxiu Wang, Xiaomin Chen, Yang Liu, Siqi Wang, Qiuyu Xiang, Yu Zhao, Lixiu Luo, Yanling Wu, Chunlan Huang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13341582.txt.
Description
Hongxiu Wang and co-authors published a research paper in 2026 on a helper protein that fuels multiple myeloma, a cancer of plasma cells in the bone marrow. The cancer returns often and resists cure, so new targets are prized. The protein, CCT2, helps fold other proteins and was found at high levels in patients.
Higher CCT2 tracked with more plasma cells in the marrow and with shorter survival. In lab cells and in mice, the protein sped tumor growth. Silencing it woke a famous guard pathway, p53, halted the cell cycle, and pushed cells to die. The team names CCT2 as a candidate drug target.
Catalog record
| CREATOR | Hongxiu Wang, Xiaomin Chen, Yang Liu, Siqi Wang, Qiuyu Xiang, Yu Zhao, Lixiu Luo, Yanling Wu, Chunlan Huang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |