Hierarchical-circular model of biological memory: a multilevel hypothesis for pathogenesis and allostatic integrity in Alzheimer’s disease and related dementias
Samuel Ruesga Mundo · 2026
Read Hierarchical-circular model of biological memory: a multilevel hypothesis for pathogenesis and allostatic integrity in Alzheimer’s disease and related dementias by Samuel Ruesga Mundo (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13341510.txt.
Description
Dementia reframed as a failure of the body's memory is proposed by Samuel Ruesga Mundo in a 2026 hypothesis paper. Decades of amyloid- and tau-centered work have produced few disease-changing therapies, and puzzles like pathology without symptoms motivate a broader frame.
His Hierarchical-Circular Model runs on the principle signal, plasticity, stable state, across five levels from genetic programming and epigenetic memory to allostatic load, a psycho-neuro-endocrine-immune network, and interoceptive brain integration. Disturbance at any level can ripple both ways and lock in harmful stable states that surface as dementia. The write-up draws on multisystem studies from 2010 to 2025.
Catalog record
| CREATOR | Samuel Ruesga Mundo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71268 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |