Esculentoside A mitigates oxidative stress and neuronal apoptosis in spinal cord injury by modulating the Nrf2/HO-1 pathway
Guoqing Zhu, Weiwei Li, Mengge Sun, Jingyu Yan, Wei Hu · 2026
Read Esculentoside A mitigates oxidative stress and neuronal apoptosis in spinal cord injury by modulating the Nrf2/HO-1 pathway by Guoqing Zhu, Weiwei Li, Mengge Sun, Jingyu Yan, Wei Hu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13341455.txt.
Description
A plant saponin protecting the injured spinal cord is tested by Guoqing Zhu's team in a 2026 rat study. Esculentoside A, drawn from Phytolacca esculenta, was given daily at 10 mg/kg after a contusion injury made with a standardized impactor.
Treated rats scored better on walking scales, grid walking, and footprint tests, and their cord tissue showed less damage under several stains. Oxidative markers fell while protective enzymes rose. Blotting, imaging, and docking work pointed to the Nrf2/HO-1 pathway as the mechanism damping both oxidative stress and neuron death. The findings nominate the compound for further development.
Catalog record
| CREATOR | Guoqing Zhu, Weiwei Li, Mengge Sun, Jingyu Yan, Wei Hu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36569 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |