From screening to treatment: in vitro and in vivo efficacy of phage-meropenem combination against highly virulent Carbapenem-resistant Acinetobacter baumannii
Lan Liao, Shanchen Yang, Gang Luo, Ruidong Wu, Rongjing Lu, Yushan Huang, Guanfeng Wu, Wei Yi, Zhu Zeng, Zhilang Qiu, Jian Peng · 2026
Read From screening to treatment: in vitro and in vivo efficacy of phage-meropenem combination against highly virulent Carbapenem-resistant Acinetobacter baumannii by Lan Liao, Shanchen Yang, Gang Luo, Ruidong Wu, Rongjing Lu, Yushan Huang, Guanfeng Wu, Wei Yi, Zhu Zeng, Zhilang Qiu, Jian Peng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13340115.txt.
Description
Lan Liao and a large team pair a phage with meropenem against highly virulent resistant Acinetobacter baumannii in a 2026 study. Among 199 clinical resistant isolates, strain CRAB110 proved most virulent in moth larvae and mice as reported. Its strength may follow disordered inflammation signals.
A new phage, P2, with wide reach and strong killing was selected against that strain. Phage-exposed mutants grew more drug-sensitive and less virulent. Combined phage plus antibiotic cleared bacteria better than phage alone in dishes and animals as reported. Genome study of the mutant begins to explain the trade-off, supporting combination therapy design.
Catalog record
| CREATOR | Lan Liao, Shanchen Yang, Gang Luo, Ruidong Wu, Rongjing Lu, Yushan Huang, Guanfeng Wu, Wei Yi, Zhu Zeng, Zhilang Qiu, Jian Peng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54182 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |