Mulberroside A attenuates H2O2-induced oxidative stress and barrier dysfunction in Caco-2 cells through Nrf2/HO-1-associated antioxidant signaling
Jianxin Chen, Xiufeng Huang, Xi Chen, Wenhai Jin, Dawei Lin · 2026
Read Mulberroside A attenuates H2O2-induced oxidative stress and barrier dysfunction in Caco-2 cells through Nrf2/HO-1-associated antioxidant signaling by Jianxin Chen, Xiufeng Huang, Xi Chen, Wenhai Jin, Dawei Lin (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13339011.txt.
Description
Jianxin Chen and colleagues test mulberroside A on stressed gut cells in a 2026 lab study. Hydrogen peroxide was used to injure Caco-2 intestinal cells, mimicking oxidative harm to the gut barrier. Survival, reactive oxygen, and barrier tightness were measured.
The compound lowered oxidative stress and restored barrier function in the reported tests. It moved the defense switch Nrf2 into the nucleus and raised protective proteins HO-1 and NQO1. Silencing Nrf2 weakened those gains, tying protection to that pathway. Results support study of this plant compound for gut disorders where oxidation damages the lining.
Catalog record
| CREATOR | Jianxin Chen, Xiufeng Huang, Xi Chen, Wenhai Jin, Dawei Lin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31411 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |