Deciphering Physicochemical Properties of Urinary Proteins from Stone Formers as Macromolecular Prolithogenic Factors to Drive Calcium Oxalate Stone Development
Sudarat Hadpech, Paleerath Peerapen, Visith Thongboonkerd · 2026
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Description
Sudarat Hadpech and colleagues hunted the chemical traits in 2026 that make urine proteins promote calcium oxalate kidney stones. Earlier work had named several stone promoting proteins from stone formers, yet the properties behind their effect stayed undefined. The team split stone former urine proteins into 15 fractions and tested each in crystal assays.
Proteins in each fraction were identified by tandem mass spectrometry, and their traits were correlated with crystal promoting activity. Most fractions boosted crystal formation. Pinning down which traits drive stone growth could guide new ways to block stones, from diet advice to drugs that blunt the worst protein effects.
Catalog record
| CREATOR | Sudarat Hadpech, Paleerath Peerapen, Visith Thongboonkerd |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |