Structure-guided identification of small molecules potentially able to modulate GDF15 activity
Antonio Chiariello, Lorenzo Lenti, Lorenzo Trofarello, Manuela Sollazzo, Mattia Lauriola, Alberto Del Rio, Stefano Salvioli, Marco Daniele Parenti, Maria Conte · 2026
Read Structure-guided identification of small molecules potentially able to modulate GDF15 activity by Antonio Chiariello, Lorenzo Lenti, Lorenzo Trofarello, Manuela Sollazzo, Mattia Lauriola, Alberto Del Rio, Stefano Salvioli, Marco Daniele Parenti, Maria Conte (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13338363.txt.
Description
Antonio Chiariello and co-workers search for small molecules that can modulate the protein GDF15, in a 2026 paper. GDF15 is linked to conditions such as cancer cachexia, the wasting that accompanies some cancers. Antibodies and peptides can block it, but whether small organic molecules can was unknown.
A structure-based computer screen of a curated library ranked candidate binders for both single and paired forms of the protein. Lab tests followed in cell-free systems and in skin and ovarian cancer cells. One compound disturbed the protein pair's stability and its binding to its receptor, and shifted downstream signals in cancer cells. The authors call for optimization work.
Catalog record
| CREATOR | Antonio Chiariello, Lorenzo Lenti, Lorenzo Trofarello, Manuela Sollazzo, Mattia Lauriola, Alberto Del Rio, Stefano Salvioli, Marco Daniele Parenti, Maria Conte |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |