Sesamin attenuates atherosclerosis by alleviating vascular endothelial ferroptosis-related injury via m6A-dependent regulation of SREBF1 expression
Xiaoying Chen, Guanyi Zheng, Kailong Fu, Minglong Yao, Kan Lin · 2026
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Description
Xiaoying Chen and colleagues test sesamin, a compound from a Chinese herbal formula, against artery disease in a 2026 study. The focus was ferroptosis, an iron-linked form of cell injury in vessel lining cells. A chemical mark on RNA that controls a fat-making gene sits at the center.
Network analysis flagged sesamin as a key active part of the formula. In mice lacking ApoE, sesamin lowered aortic fat buildup and vessel injury and improved blood lipids as reported. In human vein cells harmed by oxidized fat, it eased injury. Gene silencing and methylation tests traced protection to the METTL3 and SREBF1 pathway.
Catalog record
| CREATOR | Xiaoying Chen, Guanyi Zheng, Kailong Fu, Minglong Yao, Kan Lin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56545 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |