Cerebellar aging is spatially heterogeneous and supports cognitive resilience in later life
Federico d’Oleire Uquillas, Esra Sefik, Jakob Seidlitz, Edan Daniel Hertz, Rafael Romero-Garcia, Varun Warrier, Richard A. I. Bethlehem, Aaron F. Alexander-Bloch, Jonathan D. Cohen, Samuel S.-H. Wang, Jorge Sepulcre, Patrizia Vannini, Jesse Gomez · 2026
Read Cerebellar aging is spatially heterogeneous and supports cognitive resilience in later life by Federico d’Oleire Uquillas, Esra Sefik, Jakob Seidlitz, Edan Daniel Hertz, Rafael Romero-Garcia, Varun Warrier, Richard A. I. Bethlehem, Aaron F. Alexander-Bloch, Jonathan D. Cohen, Samuel S.-H. Wang, Jorge Sepulcre, Patrizia Vannini, Jesse Gomez (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13337503.txt.
Description
Federico d’Oleire Uquillas leads a large 2026 team mapping how the cerebellum ages across 47,000 adults in three imaging studies. This back-brain structure holds most brain neurons and supports thought as well as movement, yet its aging pattern was murky. Volume and tissue-ratio measures, backed by quantitative scans in an independent sample, charted the changes.
Aging proved uneven: association and motor-related regions declined faster with age than other lobules. Bigger cerebellar volume tracked with higher cognitive scores as age rose, suggesting reserve that protects function. In Alzheimer's patients the link held mainly at lower amyloid burden, even in high genetic risk carriers. The cerebellum emerges as an active guardian of late-life cognition, until disease overwhelms it.
Catalog record
| CREATOR | Federico d’Oleire Uquillas, Esra Sefik, Jakob Seidlitz, Edan Daniel Hertz, Rafael Romero-Garcia, Varun Warrier, Richard A. I. Bethlehem, Aaron F. Alexander-Bloch, Jonathan D. Cohen, Samuel S.-H. Wang, Jorge Sepulcre, Patrizia Vannini, Jesse Gomez |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 91331 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |