Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh · 2026
Read Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis by Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13337106.txt.
Description
Hui Zheng and co-authors turn ultrasound into an epigenetic signal for arthritic joints in a 2026 study. Cartilage has no blood vessels, so drugs reach it poorly in osteoarthritis. Their gel hides cartilage-camouflaged piezoelectric particles in a dynamic network that targets cartilage actively.
Ultrasound makes the particles generate tiny electric signals, opening calcium channels and activating AMPK. That suppresses the mTOR pathway and adds an acetyl mark at the GATD3A gene, raising its output. GATD3A steadies a cleanup system that clears damaged power units and cuts oxidative stress. In a mouse knee model the activated gel eased cartilage loss, bone spurs, and joint inflammation, and it worked in human cartilage samples too.
Catalog record
| CREATOR | Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 82673 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |