A Single‐Cell Transcriptomic Atlas of the Ovine Rumen Microbiome Characterizes Lineage‐Specific Metabolic Shifts Associated with Host Heat Tolerance
Sanbao Zhang, Qinyang Jiang, Junjie Ma, Jianwei Zou, Fan Wang, Feifei Lv, Yanna Huang, Yongcheng Wang, Ziye Xu · 2026
Read A Single‐Cell Transcriptomic Atlas of the Ovine Rumen Microbiome Characterizes Lineage‐Specific Metabolic Shifts Associated with Host Heat Tolerance by Sanbao Zhang, Qinyang Jiang, Junjie Ma, Jianwei Zou, Fan Wang, Feifei Lv, Yanna Huang, Yongcheng Wang, Ziye Xu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13336951.txt.
Description
Sanbao Zhang and co-authors map the sheep rumen microbiome one cell at a time in a 2026 atlas study. Tough microbial walls had blocked fair single-cell profiling of this gut community. A tuned 25 min enzyme lysis method let them profile 60 748 cells across 21 samples, resolving 213 genera and 662 species in the dataset.
Seven cross-species functional clusters emerged, tying lifestyle to metabolic specialty. In heat-tolerant hosts, energy clusters switched on fast, and one species shifted toward sugar-burning in a way that spared nutrition for the host. The atlas gives rumen ecology a reference map and a method for probing how whole communities flex under stress like heat.
Catalog record
| CREATOR | Sanbao Zhang, Qinyang Jiang, Junjie Ma, Jianwei Zou, Fan Wang, Feifei Lv, Yanna Huang, Yongcheng Wang, Ziye Xu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66696 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |