A Metal‐Phenolic Nanocluster Orchestrates Mito‐Ca2+ Metabolic Autonomy for Tumor Ca2+ Interference Therapy
Ronglong Chen, Jia Huang, Yuepeng Wang, Shucong Yao, Fei Wu, Juan Liu, Chunxue Song, Li Lin, Xijun Lin, Yingjie Deng, Chao Zhang, Zhiquan Huang, Zixian Huang, Lisi Xie · 2026
Read A Metal‐Phenolic Nanocluster Orchestrates Mito‐Ca2+ Metabolic Autonomy for Tumor Ca2+ Interference Therapy by Ronglong Chen, Jia Huang, Yuepeng Wang, Shucong Yao, Fei Wu, Juan Liu, Chunxue Song, Li Lin, Xijun Lin, Yingjie Deng, Chao Zhang, Zhiquan Huang, Zixian Huang, Lisi Xie (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13336888.txt.
Description
Ronglong Chen and a large team overload tumor power units with calcium in a 2026 nanomedicine study. Flooding mitochondria with calcium can destroy tumors, but cancer cells pump and gate calcium tightly to protect themselves. Their metal-phenolic nanocluster, TCMH, packs calcium plus two gate modulators inside a polyphenol shell.
Acid inside tumor cells breaks the cluster open. Released signals suppress mitochondrial fusion and add hydrogen sulfide, jointly forcing the calcium gate open. Calcium surge and rising harmful oxygen species then feed each other, driving cell suicide from the power unit outward. The therapy worked strongly in mouth cancer models, including patient-derived grafts. Rewiring calcium self-control could sharpen this treatment class.
Catalog record
| CREATOR | Ronglong Chen, Jia Huang, Yuepeng Wang, Shucong Yao, Fei Wu, Juan Liu, Chunxue Song, Li Lin, Xijun Lin, Yingjie Deng, Chao Zhang, Zhiquan Huang, Zixian Huang, Lisi Xie |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49975 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |