Toward Nano‐Nutritional Medicine: A Remotely Activated Trans‐Vaccenic Acid‐Based Lipid Nanoparticles for Enhancing Immune Checkpoint Blockade Therapy
Kang Liu, Yunlong Li, Hanmeng Liu, Peng Zhang, Mingjing Wang, Quanwei Sun, Wenshuo Yang, Zhengwei Song, Song Tan, Ye Yang, Peng She, Dengke Yin, Wei Shen · 2026
Read Toward Nano‐Nutritional Medicine: A Remotely Activated Trans‐Vaccenic Acid‐Based Lipid Nanoparticles for Enhancing Immune Checkpoint Blockade Therapy by Kang Liu, Yunlong Li, Hanmeng Liu, Peng Zhang, Mingjing Wang, Quanwei Sun, Wenshuo Yang, Zhengwei Song, Song Tan, Ye Yang, Peng She, Dengke Yin, Wei Shen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13336454.txt.
Description
Kang Liu and colleagues present 2026 light-activated TVA lipid nano-bits for boosting immune blockade therapy. Nutrient tuning of tumor immune defense beats making new immune drugs, yet clinic use is slowed by low oral uptake. The authors put forward nano-food care: IR780 packed in lipid nano-bits with a blend of TVA and stearin.
The blend melts at 40.5 degrees Celsius and acts as gated phase-change stuff, fired by near-IR light to release TVA. Versus oral free TVA, these nano-bits increase in-tumor TVA levels by 21.86-fold. These nano-bits show light-heat killing and spark defense. Later, the freed TVA not only cuts CD8-positive T cell tiredness by switching on cAMP-PKA-CREB axis, but lowers PD-1 levels in T cells. It also raises PD-L1 levels in tumor cells, boosting PD-L1 blockade therapy in hot and cold models.
Catalog record
| CREATOR | Kang Liu, Yunlong Li, Hanmeng Liu, Peng Zhang, Mingjing Wang, Quanwei Sun, Wenshuo Yang, Zhengwei Song, Song Tan, Ye Yang, Peng She, Dengke Yin, Wei Shen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 79 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |