Tumor Microenvironment‐Responsive Nanoreactor Induces Disulfidptosis in Pancreatic Cancer via Metabolic Interference and Redox Catalysis
Rui Fu, Qing Li, Guanzhong Zhao, Qingyan Gao, Huantong Chen, Khemayanto Hidayat, Jiaying Xu, Liqiang Qin, Chunhong Hu, Yu Chong, Su Hu · 2026
Read Tumor Microenvironment‐Responsive Nanoreactor Induces Disulfidptosis in Pancreatic Cancer via Metabolic Interference and Redox Catalysis by Rui Fu, Qing Li, Guanzhong Zhao, Qingyan Gao, Huantong Chen, Khemayanto Hidayat, Jiaying Xu, Liqiang Qin, Chunhong Hu, Yu Chong, Su Hu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13336420.txt.
Description
Rui Fu and co-authors designed a nanoreactor that starves pancreatic cancer cells into a sulfur-stress death in a 2026 nanomedicine study. Pancreatic tumors rewire metabolism to grow fast and resist therapy, and that rewiring creates exploitable weak points.
The particle targets CD44 on tumor cells and, once inside the tumor environment, releases phloretin, which throttles glucose uptake and the pentose phosphate pathway, cutting the cell's supply of reducing power. Its manganese dioxide shell meanwhile burns through glutathione and amplifies oxidative stress. Caught between too little reducing power and too much oxidation, cells pile up cystine, suffer disulfide stress, and their actin skeleton collapses in the death program called disulfidptosis. Released manganese also lights the tumor on MRI scans.
Catalog record
| CREATOR | Rui Fu, Qing Li, Guanzhong Zhao, Qingyan Gao, Huantong Chen, Khemayanto Hidayat, Jiaying Xu, Liqiang Qin, Chunhong Hu, Yu Chong, Su Hu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50522 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |