Surfaceome Reprogramming of Stemsomes Promotes Lung Cancer Targeting via Potentiated Receptor–Ligand Interactions
Geunhye Kim, In Ah Kwon, Bo Seop Jeong, Hyo Seon Kim, Joo‐Hwan Park, Sung Jean Park, Sang‐Rae Lee, Youngki Lee, Dongwoo Khang · 2026
Read Surfaceome Reprogramming of Stemsomes Promotes Lung Cancer Targeting via Potentiated Receptor–Ligand Interactions by Geunhye Kim, In Ah Kwon, Bo Seop Jeong, Hyo Seon Kim, Joo‐Hwan Park, Sung Jean Park, Sang‐Rae Lee, Youngki Lee, Dongwoo Khang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13336371.txt.
Description
Geunhye Kim and colleagues study 2026 surface protein rewiring of stem sacs promoting lung cancer targeting via potentiated receptor-ligand interactions. Non-small-cell lung cancer death rate remains high because mutation-matched treatments target only small patient subsets and always face drug pushback. In this regard, multi-pathway stem sacs offer a hopeful broad platform for beating unmet needs of lung cancer treatments, especially for patients lacking known cancer drivers.
This study presents a new plan in which dexamethasone, a compound normally used as an anti-swelling drug, is reused to boost tumor-targeting power of stem sacs. Nano-bits made by fusing drug-primed stem sacs with liposomes exhibit greatly improved treatment effects. According to gene-reading and siRNA knockdown tests, this enhanced tumor aiming of tumor cells is driven by drug-induced rise of key cell stick proteins, specifically ephrin type-A receptor 2.
Catalog record
| CREATOR | Geunhye Kim, In Ah Kwon, Bo Seop Jeong, Hyo Seon Kim, Joo‐Hwan Park, Sung Jean Park, Sang‐Rae Lee, Youngki Lee, Dongwoo Khang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |