HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang · 2026
Read HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism by Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13336110.txt.
Description
Chang Zhang and colleagues study 2026 HNRNPU K181 lactate tagging driving cervix cancer growth by raising PHGDH and rewiring serine use. Cervix cancer remains a major global health burden, yet gene workings driving its metabolic rewiring are not fully known. The authors find mixed nuclear protein U as a novel non-histone substrate of lysine lactate tagging that links lactate buildup to serine use and tumor growth.
They show that lactate tagging at lysine 181 steadies HNRNPU, enhances its binding to PHGDH mRNA, and maintains the exon 1 PHGDH transcript and mRNA hold. This keeps PHGDH levels and switches on the serine making pathway. This rewiring promotes redox balance, DNA-block making, and cervix cancer cell growth both in vitro and in vivo. In detail, they reveal a rival link between lactate tagging and NAA50 tagging at lysine 181. This establishes a dynamic after-making switch that fine-tunes HNRNPU function.
Catalog record
| CREATOR | Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 112 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |