An Integrated DNA Nanoprobe for Intranuclear Imaging and In Situ Profiling of OGG1 Activity
Mingzhu Zhao, Xuemei Sun, He Li, Bangming Wang, Mengting Pan, Zhen Ma, Rong‐Mei Kong, Weiheng Kong, Yan Zhao, Fengli Qu · 2026
Read An Integrated DNA Nanoprobe for Intranuclear Imaging and In Situ Profiling of OGG1 Activity by Mingzhu Zhao, Xuemei Sun, He Li, Bangming Wang, Mengting Pan, Zhen Ma, Rong‐Mei Kong, Weiheng Kong, Yan Zhao, Fengli Qu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13336051.txt.
Description
Mingzhu Zhao and colleagues present 2026 a combined DNA nano-probe for in-nucleus imaging and in situ mapping of OGG1 action. However, due to hard nucleus placement and weak signal output, cell-level imaging has not yet been achieved.
The authors report a nucleus-aimed DNA prism nano-probe designed to beat these limits via a two-part plan. The nano-probe combined an AS1411 aptamer for active nucleus drop-off and a FRET array for signal readout. In living cells, the nano-probe enabled watching of nuclear OGG1 action, showing distinct shifts in base enzyme levels across different cell lines. Also, early tests in lung wash fluid from pneumonia patients suggested its use in clinic settings. It also served as a testbed for drug checks, effectively testing OGG1-aimed drugs.
Catalog record
| CREATOR | Mingzhu Zhao, Xuemei Sun, He Li, Bangming Wang, Mengting Pan, Zhen Ma, Rong‐Mei Kong, Weiheng Kong, Yan Zhao, Fengli Qu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |