A Bone Marrow–Mimetic Hydrogel Enables Dual‐Phase Hemostasis and Vascularized Osteogenesis for Cranial Defects
Lingbin Che, Donghong Li, Huan Zhang, Tingting Xu, Juhan Li, Xuanzhou Chen, Louis D. Zhang, Shuguang Wang, Dianwen Song, Dongyong Sha · 2026
Read A Bone Marrow–Mimetic Hydrogel Enables Dual‐Phase Hemostasis and Vascularized Osteogenesis for Cranial Defects by Lingbin Che, Donghong Li, Huan Zhang, Tingting Xu, Juhan Li, Xuanzhou Chen, Louis D. Zhang, Shuguang Wang, Dianwen Song, Dongyong Sha (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13335774.txt.
Description
Big holes in the skull pose two problems in sequence: bleeding now and missing bone later. Lingbin Che and co-authors engineer a gel that imitates bone marrow to handle both. The composite mixes a gelatin network set by an enzyme, stiff short fibers coated with a sticky polymer, and an extract drawn from fat tissue that carries growth signals.
The fibers plug the wound mechanically while the coating helps clots hold, giving fast blood control. Then the extract leaks out slowly, calling in repair cells, encouraging blood vessel growth, and nudging stem cells toward bone. In rats with large skull defects, the gel also calmed inflammation and produced mature, well-vascularized new bone. Gene analysis tied the effect to a known growth pathway.
Catalog record
| CREATOR | Lingbin Che, Donghong Li, Huan Zhang, Tingting Xu, Juhan Li, Xuanzhou Chen, Louis D. Zhang, Shuguang Wang, Dianwen Song, Dongyong Sha |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |