Reinnervation of Muscle Targets Enhances the Separability of Motor Unit Signals Following Peripheral Nerve Transfers
Kiara N Quinn, Siyu Wang, Lang Qin, Alessandro Ascani Orsini, Kenzi Griffith, Rachana Suresh, Fausto Kang, Pierce L Perkins, Neha Joshi, Alexis L Lowe, Sami Tuffaha, Nitish V Thakor · 2026
Read Reinnervation of Muscle Targets Enhances the Separability of Motor Unit Signals Following Peripheral Nerve Transfers by Kiara N Quinn, Siyu Wang, Lang Qin, Alessandro Ascani Orsini, Kenzi Griffith, Rachana Suresh, Fausto Kang, Pierce L Perkins, Neha Joshi, Alexis L Lowe, Sami Tuffaha, Nitish V Thakor (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13335489.txt.
Description
Kiara Quinn and co-authors show, in twenty twenty-six, that reinnervating muscle targets makes motor unit signals easier to separate after nerve transfer surgery. After amputation, prostheses often decode intent from pooled muscle signals, which limits natural control. Splitting the signal into single motor units promises finer control, but overlapping units blur together. The team tested direct nerve-to-muscle implantation in a rodent hindlimb model. Tissue and electrical analyses followed the reinnervation.
Structural changes after surgery spread motor unit signals farther apart in space than in intact muscle. That separation meant fewer complex, overlapping signals in recordings. The team used the cleaner signals for a first proof-of-concept: precise control of a virtual prosthesis after direct nerve-to-muscle implantation.
Catalog record
| CREATOR | Kiara N Quinn, Siyu Wang, Lang Qin, Alessandro Ascani Orsini, Kenzi Griffith, Rachana Suresh, Fausto Kang, Pierce L Perkins, Neha Joshi, Alexis L Lowe, Sami Tuffaha, Nitish V Thakor |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |