Severe Hypoprothrombinemia Associated With Vitamin K Deficiency During Prolonged Cefazolin Therapy in a Hemodialysis Patient
Mari Morimoto, Yu Mihara, Munehiro Yoshida, Yasuto Sunahara, Nariko Ikemura, Kayo Kitamoto, Tetsuro Kusaba, Ryosuke Hamashima, Yoichi Yuki, Tohru Inaba, Keiichi Tamagaki · 2026
Read Severe Hypoprothrombinemia Associated With Vitamin K Deficiency During Prolonged Cefazolin Therapy in a Hemodialysis Patient by Mari Morimoto, Yu Mihara, Munehiro Yoshida, Yasuto Sunahara, Nariko Ikemura, Kayo Kitamoto, Tetsuro Kusaba, Ryosuke Hamashima, Yoichi Yuki, Tohru Inaba, Keiichi Tamagaki (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13335408.txt.
Description
Mari Morimoto and colleagues report a 2026 case of severe low prothrombin linked to vitamin K lack during long cefazolin therapy in a kidney patient. A 73-year-old man on maintenance dialysis for end-stage kidney disease from diabetic kidney damage was hospitalized for pus-filled ankle tendon infection and treated with the drug. During hospitalization, he had persistent anorexia and recurrent gut bleeding. On a day without treatment, he developed an under-skin bruise around the artery-vein fistula.
Despite no blood thinner use, clotting times were much longer. Lab findings showed reduced activity of vitamin K-dependent clotting factors and a much higher vitamin K absence protein level, indicating vitamin K lack. IV vitamin K and switching the antibiotic from the drug to ampicillin followed.
Catalog record
| CREATOR | Mari Morimoto, Yu Mihara, Munehiro Yoshida, Yasuto Sunahara, Nariko Ikemura, Kayo Kitamoto, Tetsuro Kusaba, Ryosuke Hamashima, Yoichi Yuki, Tohru Inaba, Keiichi Tamagaki |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 18 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |